Quinine

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QUININE

INDICATION:

  • It is a potent anti-malaria drug used for malaria particulary for the brain.

DOSAGE AND ADMINISTRATION.

Treatment of Malaria

Formualtions: 600mg/2ml and 300mg/1ml.

Dosage and Administration:

Quininie Dilhydrochloride is given by slow intravenous infusion (in 5% Dextrose injection) over 2-4 hours.

The usual adult pre-operative dose of Pethidine hydochloride is 50 to 100mg IM or subcutaneously 30 to 90 minutes before the beginning of anaesthesia.

Recommended adult dose: 600mg by slow IV infusion over 2-4 hours; the dose is repeated every 8 hours until oral therapy can be initiated. The maximum adult IV dosage is 1.8g daily.

IV administration in children, the usual daily dose of quinine dihydrochloride recommended is 25mg/kg body weight.

PRECAUTIONS AND CONTRAINDICATIONS:

is contraindicated in patients with G-6-PD deficiency. Because Quinine is contraindicated in patients who are hypersenitive to the drug. Patients hypersensitive to quinine should be warned to avoid food products and drug preparations for self-medication that contain the drug (eg. tonic water, certain cold preparations). Patients aslo should be warned to discontinue the drug and contact a physician if tinnitus, hearing loss, rash or visual disturbances occurs during quinine therapy.

Quininie thrombocytopenic purpura may occur during the therapy with quninie in highlt sensitive patients, a history of this adverse hematologic effect with previous administration of quininie is also a contraindication for use of the drug. Quininie is also contraindicated in patients with tinnitus or optic neuritis and in patients with a history of blackwater fever.

ADVERSE REACTION:

Cinchonism: this term denotes the mild toxic state that usually develops when the plasma level of quininie exceeds 10-12mg.L. Symptoms include flushed and sweaty skin, tinnitus blurred vision, imparied hearing, dizziness, nausea.

USE IN PREGNANCY AND LACTATION

Cinchonism: this term denotes the mild toxic state that usually develops when the plasma level of quininie exceeds 10-12mg.L. Symptoms include flushed and sweaty skin, tinnitus blurred vision, imparied hearing, dizziness, nausea.

TREATMENT OF OVERDOSE

In acute over dosage of quinine, the stomach should be emptied y gastric lavage or bt emesis enduced with ipecac. Measures should be used to maintain renal function, and boold pressure should be supported; fluid and electrolyte balance should be maintained with IV fluids..

STORAGE CONDITIONS

Store in cool dry place and protect from light..