- Pethidine Hydrochloride Injection contains 50mg of Pethidine Hydrochloride per ml.
Actions and Indications.
Pethidine Hydrochloride is a strong narcotic analgesic used in the relief of moderate to severe pain. The drug has been used to relieve the pain of myocardial infraction. Pethidine is used parenterally for preoperative sedation, as an adjunct to anaesthesia and to provide analgesia during labour.
Pethidine is also used in patients with acute pulmonary oedema for its cardiovascular effects and to allay anxiety.
Dosage and Administration:
For the relief of pain, Pethidine hydrochloride is given by intramuscular and subcutaneous injection in doses of 25 to 100mg every four hours as necessary, and by slow intravenous injection in doses of 25 to 50mg/hour. In children, doses of 0.5 to 2.0mg per kg body weight may be given by intra muscular injection.
The usual adult pre-operative dose of Pethidine hydochloride is 50 to 100mg IM or subcutaneously 30 to 90 minutes before the beginning of anaesthesia.
In obstetric analgesia, 50 to 100mg may be given by intramuscular or subcutaneous injection as soon as contractions become regular. This dose may be repeated after 1 to 3 hours if necessary.
It should be given cautiously to patients with supraventricular tachycardia. Very severe reactions including coma, severe respiratory depression, cyanosis, and hypotension have occured in patients receiving mono amine oxidase inhibitors and given Pethidine.
Pethidine should not be given to patients receiving monoamine oxidase inhibitors or withing 14 days of their discontinuation.
100mg in 2ml ampoule.